Understanding biology at the single-cell level is crucial for unraveling the complexity of living systems. The past decade has seen tremendous advances in single-cell biology, pioneered by exciting methods that have pushed assays to extremely high sensitivity and resolution. As such, Nature Methods has featured single-cell methodologies as the Method of the Year three times since 2013. In this talk, I will introduce Nature Methods, describe our editorial criteria, offer tips for publishing strong methods papers, and discuss why we’re still excited about single-cell methods, both from a genomics and microscopy perspective.